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This study is limited by modest cohort size, relatively narrow geographical sampling and by the limited serological data presently available.
However, the variability of salivary cortisol between individuals and the modest cohort size did not allow any significant differences to be detected between baseline and 6 month follow-up.
The focus on global illness burden and all types of first-contact access is not only highly relevant to primary healthcare practice and policy, but also allows us to detect important effects despite the modest cohort size.
17, 18 Based on our analysis and the distortions in genotype and allele frequencies, we suggest the FAM13A effect in COPD and lung cancer is most consistent with a recessive model, the former in agreement with Cho et al. 22 The modest cohort size together with the case-control cross-sectional design may be considered as limitations of this study.
A direct comparison of the dose delivery and toxicities with this regimen relative to the other reported oxaliplatin-based CRT regimens is difficult for several reasons including: (i) the use of a split course of oxaliplatin 5-FU CRT, (ii) the impact oxaliplatin 5-FUFOX given before the start of CRT and ii the RT-free wimpact and (iii) the mofest cohort size.
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Despite the relatively modest cohort sizes, these analyses suggested evidence of genetic interaction (non-additive effects) in all three populations studied (table S8 in online supplement).
The first trial, assessing the efficacy and safety of secukinumab in patients with active PsA, revealed a modest improvement in patients as compared to controls, although the moderate results were thought to be due to the small cohort size (49).
Second, the cohort size was modest and not sufficiently large for biomarker exploration.
However, the study cohort size was modest at 60 patients which may have contributed to negative findings [ 15].
Since our cohort size was relatively modest and both TP and RP groups were small, more large-scale analyses and further evidence are needed to verify our results.
Reducing cohort size is tantamount to reducing accessibility.
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Justyna Jupowicz-Kozak
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