Sentence examples for modest clinical efficacy from inspiring English sources

Highly promising preclinical data obtained in cultured cells and in nude mice bearing xenografts contrast with the rather modest clinical efficacy of Polo-like kinase 1 (Plk1) inhibitors.

Subsequently, a first-in-human phase I dose escalation trial was performed in patients with advanced, CD44-expressing solid tumours, showing that RG7356 was well tolerated with modest clinical efficacy [10].

However, so far, p38 MAPK inhibition showed modest clinical efficacy in patients with RA [ 22].

However, the conclusions of several clinical studies have shown consistent evidence for a modest clinical efficacy of marine ω3 PUFAs in RA.

This finding offers a potential explanation for the modest clinical efficacy of available CGRP receptor antagonists and potential therapeutic opportunities for the future.

For some of the p38 MAP kinase inhibitors that advanced into clinical trials, this resulted in central nervous system effects and elevated liver enzymes that threatened to overshadow their modest clinical efficacy.

These indications have evidence of clinical efficacy with modest survival benefit (Table  1) and a resulting ICER in the range of $15,000 ~ $450,000.

In units where policies of conservative transfusion and single donors are applied, it would seem reasonable to discontinue the use of early EPO treatment for very preterm infants for which the administration procedure is painful, the large scale clinical efficacy is modest and the absence of side effects does not appear to be fully established.

Antiangiogenic therapies have been transferred from preclinical to clinical application in recent years (Ellis and Hicklin, 2008; Kerbel, 2008), but their clinical efficacy is relatively modest and a therapeutic benefit of VEGF-targeted therapy probably involves multiple mechanisms, beside its antiangiogenic effect.

However, for most solid tumors, clinical efficacy measured by overall survival benefit is modest.

Clinical trials using gene-modified DCs have shown modest results, therefore, further considerations for DC manipulation to enhance their clinical efficacy are also discussed.