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Similarly, there was a modest clinical difference in LDL concentration at 1 year among those entering the study with an elevated LDL (107.3 mg/dL intervention vs. 118.4 mg/dL usual care, P = 0.005).
Similar(59)
However, the differences seem to be of modest clinical significance (Table 2).
11 18– 20 The modest clinical improvement could account for these findings; however, this difference is not necessarily a surprise when one considers the nature of the targets.
This strategy showed very modest clinical improvement.
Conversely, patients may be very satisfied despite modest clinical gain.
First-generation epigenetic inhibitor drugs have obtained modest clinical results in two types of hematological malignancy.
Modest clinical activity was observed, but did not meet criteria for trial expansion.
However, so far, p38 MAPK inhibition showed modest clinical efficacy in patients with RA [ 22].
However, sequential lines of single-agent endocrine therapy are associated with modest clinical benefit [ 6, 7].
Based on this data, Givinostat showed modest clinical activity with tolerable toxicity.
Corticosteroids are used in COPD exacerbations despite modest clinical benefits and frequent adverse effects.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com