Sentence examples for modest clinical activity from inspiring English sources

CONCLUSIONS: Our data suggest that imatinib is active in vitro and has a modest clinical activity in carcinoid patients.

Stein, E. M. et al. The DOT1L inhibitor pinometostat reduces H3K79 methylation and has modest clinical activity in adult acute leukemia.

Epidermal growth factor receptor (EGFR) inhibitors have shown only modest clinical activity when used as single agents to treat cancers.

Trials have also been conducted with a chimeric BR96-doxorubicin conjugate (SGN-15) in a range of cancer patients with some modest clinical activity, but some immune responses towards the BR96-doxorubicin conjugates were noted [22].

Modest clinical activity was observed, but did not meet criteria for trial expansion.

Based on this data, Givinostat showed modest clinical activity with tolerable toxicity.

These data may, at least in part, explain the modest CNS clinical activity seen with lapatinib.

However, the variable lapatinib uptake in metastases demonstrates the challenge posed by tumour heterogeneity [9], a barrier for optimisation of therapy as demonstrated by the modest single-agent clinical activity [11].

The relationship reported between classical magnetic resonance imaging (MRI) metrics (total T2 lesion load and enhancing lesions) and clinical activity (relapses and disability) is usually modest in multiple sclerosis.

21 Unfortunately, early trials showed only modest clinical effectiveness in prostate cancer patients and no antitumor activity in recurrent or metastatic squamous cell carcinoma of the head and neck.

As a single agent, the clinical activity of ABT-263 has been relatively modest, particularly in solid tumors, and therefore its therapeutic utility in combination therapies has been explored.