However, most stem cell transplantation studies have yielded modest results, with cell death or displacement by the heart's contractions a significant impediment to cell engraftment and improved therapeutic outcome.
However, knockdown of autophagy mediators resulted in only a modest reversal of cell death.
These results were thus contradictory: by themselves, the inhibitors caused modest dose-dependent cell death, but when combined with PDT they dose-dependently reduced cell death.
Although, the experiment with REDD1 MEFs cannot be extrapolated to prostate cancer cells but using REDD1+/+ and REDD1−/− cells, modest resistance to cell death is observed in REDD1−/− cells as observed by cleaved-PARP and cell growth inhibition assays.
Despite inducing a modest amount of cell death as single agent, GSK690693 antagonized the ability of crizotinib to kill EBC1 cells.
Despite displaying a similar IC50 72 h) value for vorinostat to that of the HCT116 cells, HT29 cells showed only a modest increase in cell death from 2%to9.5%5% following treatment with vorinostat.
We did detect a modest increase in cell death (as determined using LysoTracker Red staining), both in the arches and throughout the head of tbx1 mutants, yet proliferation was unaffected (as determined using BrdU staining; supplementary material Fig. S2Q,S,T).
Culturing chondrocytes for 1 day in 2-deoxy-D-glucose, a glucose analog that inhibits glycolysis, caused a modest 8% increase in cell death compared with galactose culture.
In NSCLC and gastric cancer cells CM-118 as well as the approved drug crizotinib caused growth arrest in the nanomolar range that was accompanied with modest increases in tumor cell death.
Here we observed that the death of DA1-3b leukemia cells induced by RIP3-WT expression was not significantly affected in cells that were stably transfected with p65/RelA, I-kappa-B-kinase-beta (IKK β, or an IKK βSSEE constitutively active mutant. Moreover, a dominant-negative inhibitor kappa-B-alpha mutant (I κB αM) demonstrated a modest additive effect on cell death.
