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Other PTMs such as oxidation and acetylation also exhibited modest, but nonsignificant trends for lower abundance in EPA-treated old mice (Table 1).
Glucocorticoid blockade increased plasma ACTH (Fig. 2 A ), whereas metyrapone prevented any compensatory increase in plasma cortisol (Fig. 2 B ) and produced a modest but nonsignificant overall reduction in cortisol levels (P = 0.075).
Regarding the pathway of biosynthesis of PGE2 and PGD2, a higher expression of COX-2 was found (P=0.0039), whereas a modest but nonsignificant increase of PLA2 expression was also observed.
We also found that within studies our estimate of the odds ratio ignoring the matching and adjustment was very close to the adjusted matched odds ratio for all studies where we were able to estimate both, except for the study by Rosenberg et al (1994), in which matching and adjustment changed the estimate from close to one to a modest, but nonsignificant association.
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There was no association for higher birthweight in white women for the full dataset and a modest but statistically nonsignificant positive association for the restricted dataset.
For TAC mean curves by gender and time, in contrast, there were highly significant effects of beers consumed but only modest nonsignificant sex differences were seen (as a main effect trend, p < 0.1).
While findings from these pretransitional populations need to be interpreted carefully because of the selected nature of samples used, such populations tend to show positive but modest and statistically nonsignificant intergenerational fertility correlations that are usually only slightly larger than the early values of Langford and Wilson (1985) and Bocquet-Appel and Jakobi (1993).
IDI was also significant, 0.0188 (p = 0.003) but the change in C-index remained modest and nonsignificant (p = 0.277) among women.
Disruption of the Abcg5 and Abcg8 genes in mice strongly decreases the biliary cholesterol secretion but results in modest nonsignificant reductions in the biliary phospholipid levels [ 27].
A modest though nonsignificant decrease in risk for nonruptured AAA was observed among α-tocopherol supplemented men (RR 0.71, 95% CI 0.48 1.04) compared with men not receiving α-tocopherol.
There was a modest and nonsignificant association of NEFA with diabetes (Ptrend = 0.21).
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