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AS602868 for its part only induced a modest arrest at the S phase, but in combination with SN38 increased the number of cells in both S and G2/M phases.
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On the other hand, a modest G1 arrest (51 62%) observed in the parental line (HCT116) did not occur in the conditioned cells (HCP40).
NU6027 caused a modest G1 arrest in all cells (presumably by virtue of CDK2 inhibition) and was not cytotoxic per se.
The prosecutor's office has launched probes into more than 1,400 people, though its success rate is more modest: 187 arrests and 58 convictions.
The PPAR γ agonists also induced a modest cell cycle arrest and apoptosis in gliosphere cells, suggesting their anti-tumour activity in BTSCs.
The new agents demonstrated more potent CDK inhibitory activity, enhanced induction of G2/M arrest and modest apoptosis as compared to purvalanol B. Intracellular imaging of the CDK inhibitor distribution was performed to reveal drug retention in the cytoplasm of treated breast cancer cells.
Autophagy-associated ARHI-induced cell death is associated with modest G1 cell-cycle arrest and necrosis, but neither apoptosis nor senescence.
However, forced expression of BCL2 did not rescue the modest but significant G1 arrest and reduction of the proportion of cells in S phase, likely explaining why only a partial rescue was observed.
Meanwhile, the Pinochet arrest marks a modest step towards the sort of world in which powerful people think twice before they do evil.
Patients after cardiac arrest have a modest systemic inflammatory response compared to healthy controls.
Indeed, even if merely 1%percentt of transcribing polymerases experience modest pausing through, or transcriptional arrest in, a gene region, this has a striking effect on the predicted RNAPII density profile.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com