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The compounds presented modest apoptotic effects in human cancer cells.
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Exposure to 4 Gy IR had a modest apoptotic effect on shControl cells (baseline 5% apoptosis without IR to ~10% apoptotic fraction 24 h post-IR), but Annexin V staining significantly increased from 35%to50%0% for shDMC1.1068 cells and from 16%to25%5% for shDMC1.826 cells.
(C) Effects of STAT3C overexpression on SLE-mediated apoptotic effects.
Overexpression of STAT3C evidently diminished the apoptotic effects of SLE on A375 cells (Fig. 7C).
Annexin V/7-AAD double staining assay was performed to quantify the apoptotic effects of SLE on A375 cells.
Apoptotic effects were studied in human cancer cells.
Intriguingly, depletion of the IgG fraction from scleroderma sera completely abolished the apoptotic effects.
No apoptotic effects were noted.
Nedel, F. et al. Substituted diaryl diselenides: Cytotoxic and apoptotic effect in human colon adenocarcinoma cells.
This apoptotic effect could be partly prevented by the co-treatment with exogenous OPG.
Therefore, the designed AuNP specifically enhances the apoptotic effect of the delivering drug, DOX employed in this study.
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