That being said, the amount of data amassed herein suggesting the superiority of MI over mixed models in the context of RCTs is modest and further research is warranted.
Finally, our sample size was modest and further studies with larger numbers of patients should be performed to confirm our results.
However, the effects on CREB phosphorylation were rather modest and further experiments are required to unravel completely the link between retinoic acid and HDAC8 inhibitor combination treatment-induced cell death and differentiation mechanism in neuroblastoma.
However, the increase in the sensitivity of HCT-116 cells to 5-FU is quite modest and further studies are required to validate this phenomenon on more colon cancer cell lines, and even on other kinds of cancer cell lines.
The labeling differences in the three storage protein subunits were modest, and further quantification efforts of soybean protein focused on the β-conglycinin subunit that gave the greatest number of identified peptides (Table S-3).
Although the level of significance for the association with free T4 remains modest, and further larger confirmatory studies are required to validate this, our finding is supported by its replication in the same individuals 13 years later in the Busselton cohort.
