Sentence examples for modest affinity is from inspiring English sources

The small molecule must bind to the protein but only modest affinity is required.

This suggests that high-affinity (low-micromolar KD) compounds are unlikely to be found from a random screen; rather, compounds of more modest affinity are expected.

The relatively modest shift in affinity is similar to the changes observed following heterologous co-expression of normal and other mutant CaSR [31].

This modest shift in affinity is in line with the changes reported following heterologous co-expression of normal and mutant CaSR [31] and may be attributed to partial rescue of CaSR mutants by wild-type receptor (Wang and Smith, unpublished observations).

In energetic terms, this modest difference in affinity is roughly equivalent to one hydrogen bond.

Kup is a potassium uptake system of modest affinity that is found in some bacteria.

Hence compounds 34 and 35 were prepared by the route shown in Scheme 3, and although modest enzyme affinity was observed alongside excellent passive permeability (34: PAMPA Papp 217 nm s−1) and good lipophilicity (34: m Log D 1.4), in vitro anti-parasite activity and metabolic stability were poorer.

In vivo imaging protocols with the current generation of fluorescent Zn-BDPA probes typically employs relatively high doses because the membrane affinity is modest (low micromolar dissociation constant).

Also, affinity enhancement from tyrosine or lysine substitution in several positions of the peptide is consistent with the idea that, in mostly unstructured peptides, modest affinity can be achieved from a few interacting residues separated by relatively flexible non-interacting residues.

This linker does not seem ideal for larger constructs because only modest improvements in affinity are observed when more than three fingers are connected in this manner.

In the presence of 1 mM calcium, only modest changes in affinity were found (Kd value of 32.6 ± 0.15 μM).