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Some degree of response involving cytokine expression and neutrophil recruitment is clearly required for host defense against C. albicans: perhaps a modest acute host response is more successful in eradicating the fungus and avoiding progressive kidney damage than a more florid host reaction in the kidney.
The impact of even a modest acute insult to already compromised kidneys may be devastating.
Although MBL concentrations remain relatively constant in individuals due to genetic determinants, MBL is known to be a relatively modest acute phase reactant [ 37].
In turn, VILI induces a more modest acute inflammatory response with mild lung neutrophil accumulation and distinct mechanisms leading to inflammation and barrier dysfunction involving a different set of signaling molecules [ 23, 45- 47] and transcription factors [ 48].
Illness severity in this study was moderate, as evidenced by the modest Acute Physiology and Chronic Health Evaluation II scores on day 1, relatively short length of stay (LOS) in the ICU, and the ability of almost all patients to complete a structured interview within 3 days of ICU discharge.
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In addition, there are modest data that probiotics are effective in the treatment of mild acute pouchitis.
Signals from Whitehall suggested that the government would be most likely to steer a mid course, with modest increases in acute beds and a greater expansion of "intermediate" care provision for elderly patients no longer needing acute care but not fit enough to go home.
Other educational booklets or pamphlets have been previously assessed, with relatively modest effects, for acute [27], chronic [28], or occupational [29] back pain.
Evidence is increasing that antibiotics have a modest effect for acute otitis media, 8 sinusitis, 9 and bronchitis, 10 as well as sore throat.
It has been shown that even modest degrees of acute renal failure without need for haemodialysis increase the risk for death by fivefold [ 7].
Pima Indians with isolated IGT had a modest decrease in acute insulin response (AIR), as measured by an intravenous glucose tolerance test, which was significant given increased insulin resistance in subjects with IGT compared with those with NGT (17).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com