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Exact(6)
The composite photocatalyst shows also modest activity for the photodegrading of 4-chlorophenol (4-CP).
In contrast to Fpr4, CYP33 has activity for H3P16 and shows only very modest activity for H3P38.
Collectively, these data suggest modest activity for IM and S as single agents and argue that investigations of combining both these drugs in patients with CRPC are warranted.
Chen et al (2004) concluded that single-agent pulse actinomycin D had only modest activity for methotrexate-resistant GTN, with hCG levels being lower in responders (mean 37 vs 3634).
The Cys316Ser variant displayed reduced but modest activity for glycine and l-alanine relative to wild-type AlmE, while the Cys316Ala variant was equally able to adenylate glycine or l-alanine at levels below wild-type AlmE with glycine.
Other phosphoester substrates were tested and confirmed the preference of MptpB and Lmo1800 for the p-Tyr amino acid over p-Ser and p-Thr and showed modest activity for 5'AMP and 5'IMP (Table 2).
Similar(54)
Again, using different injected mRNA concentrations, the modest activity of the mutant Syndapin suggests little evidence of a dose-dependent effect for the KK→AA mutant.
However, despite the modest activity of gemcitabine as single agent in metastatic breast cancer, its favourable toxicity profile makes it an ideal candidate for combination chemotherapy.
However, the docking scoring functions used probably overestimated the weight of electrostatic interactions between the ligands and key active-site residues in the protein environment, which may account for the modest activity found for the designed inhibitors.
Dual inhibition of HER2 and EGFR did result in modest activity and provides support for combination treatment and screening for HER2 in advanced gastric cancer.
Several compounds displayed modest activity and good selectivity for Factor XIa.
Related(20)
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