Sentence examples for modest activity and from inspiring English sources

Several compounds displayed modest activity and good selectivity for Factor XIa.

During initial cancer trials, didemnin B exhibited modest activity and displayed the constraint for the treatment with anti-emetics [250].

There were no treatment-related deaths.Carboplatin, irinotecan, and bevacizumab was associated with modest activity and adequate safety among recurrent GBM patients who progressed on bevacizumab previously.

In the remaining five cell lines, L-PAM showed modest activity and induced ⩽2 logs of cell kill.

Dual inhibition of HER2 and EGFR did result in modest activity and provides support for combination treatment and screening for HER2 in advanced gastric cancer.

Currently there are limited options to hormone replacement therapy as non-hormonal pharmacological agents are associated with only modest activity and many adverse side effects.

Recently performed targeted therapy approaches with the Her/2-neu and/or EGFR inhibitors lapatinib or erlotinib have shown no or only modest activity (0 and 8% responses, respectively) in advanced biliary system adenocarcinomas (Philip et al, 2006; Ramanathan et al, 2006).

Other phosphoester substrates were tested and confirmed the preference of MptpB and Lmo1800 for the p-Tyr amino acid over p-Ser and p-Thr and showed modest activity for 5'AMP and 5'IMP (Table 2).

Trastuzumab had no detectable anti-growth effect, but BH5 and BH6 displayed only modest activity (27% and 35% growth inhibition, respectively; p < 0.02).

Collectively, these data suggest modest activity for IM and S as single agents and argue that investigations of combining both these drugs in patients with CRPC are warranted.

An example of a drug with clear preclinical activity and modest activity in the clinic is recombinant human TNF-related apoptosis-inducing ligand (rhTRAIL) or Dulanermin.