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However, the roots of Dichrostachys cinerea revealed modest activities with RSA of 27.4% [51].
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In conclusion, weekly schedule of docetaxel and gemcitabine has modest activity with acceptable toxicity profile in advanced NSCLC, but as high frequency of early discontinuation occurred does not merit further study with the present regimen.
Previous phase II studies of continuous infusion Fluorouracil (5-FU) (CI 5-FU) in refractory metastatic breast cancer have shown modest activity with low toxicity.
CONCLUSIONS: In patients with advanced gastric and esophageal cancer who were not candidates for every-3-week DCF, a weekly formulation of DCF demonstrated modest activity with minimal hematologic toxicity, suggesting that weekly DCF is a reasonable treatment option for such patients.
Gemcitabine-based chemotherapy for locally advanced or metastatic PDAC has only modest activity with a small survival benefit [3].
In conclusion, temsirolimus appears to have only modest activity with a manageable toxicity profile in advanced NEC.
Mesa et al. demonstrated modest activity with a similar regimen, but no resolution of fibrosis was demonstrated.
The combination had modest activity, with PR in only two patients, and stable disease in 15 patients.
Interestingly, the purified MCM2 7 complex does not show helicase activity in vitro, whereas a subcomplex of Mcm4, Mcm6 and Mcm7 presents modest activity with low processivity (Ishimi, 1997).
It was surprising to see the sulfone-linked analogue 49 exhibiting only modest activity with an IC50 value of 1787 n m.
A phase II trial of sorafenib in 37 metastatic melanoma patients reported a modest activity, with only three partial response (8% Min et al, 2008).
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