Sentence examples for modest activation of from inspiring English sources

We know the mutations associated with developmental syndromes cause a modest activation of MEK activity compared with activating mutations in the activation segment.

In the presence of glutamine and PII-UMP, addition of ATN6 provided modest activation of the AT activity.

Such a model would fit with the modest activation of core GEF activity seen on rabaptin binding.

AKB-4924 is a PHD inhibitor that results in modest activation of HIF-2α but robustly activates HIF-1α [23].

Western blot analyses of Jak3 and Stat3 phosphorylation of T-cell protein extracts showed strong activation of Jak3 and modest activation of Stat3 upon S100A4 treatment, whereas the S100A4 mutant protein did not activate the phosphorylation.

This could be consistent with modest activation of the renin-angiotensin-aldosterone system (RAS) [22],[22].

Similar to the DBTRG-05MG cells, there was a modest activation and Thr phosphorylation of AMPK in response to A769662, but both were enhanced when Akt was inhibited using MK2206.

Another class of mutations that leads to modest activation is found in the ATP-binding glycine-rich loop.

We have focused on regulation by metabolic intermediates and, although modest, the activation of the enzyme by the glycolytic intermediate Fru-6P as described in the present study could have a physiological role in mycobacteria.

However, Silver et al [11] showed modest but reliable activation of IPS1 and IPS2 in response to passive stimulation.

In contrast, there was a modest TGFβ dependent activation of kinase pathways (PI3K, ERK and JNK MAPK) in BE adenocarcinoma cells (Figure 5).