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It is, therefore, intriguing to speculate that even modest accumulation of radioactivity in the nucleoli, by causing disruption of stress-response co-ordination, could have a disproportionately detrimental effect on cell survival.
Note that there was a tendency for the glutamate concentration to increase each day of the 5 days MSG session, which suggests that a modest accumulation of glutamate was occurring.
Although multiple symptoms are apparent in patients, Fabry mouse models are relatively normal except for modest accumulation of GL-3.
DNA damage results in only a modest accumulation of conjugates as monitored by Western blotting unless USP1 is disrupted, in which case much higher steady state levels are observed [5], [14].
The level of pro-caspase-8 expression did not change during this process, however, we did detect a modest accumulation of the DED domains among differentiating and non-proliferative cells (Figure 1C, right).
15 Multiple dosing studies showed little to modest accumulation of raltegravir.
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While hPCFT expression is more limited in normal tissues than hRFC, even if hPCFT is present, the decreased electrochemical proton gradient would result in only modest accumulations of hPCFT substrates such as compound 16.
As with HD patients, steady state appeared to be attained within 2 3 days of dosing, with a modest accumulation in exposure (ARAUCtau = 1.6).
The vast majority of the transcripts enriched in L. major promastigotes (86%) showed a modest accumulation not exceeding 3-fold.
Only modest accumulation is reported after multiple-dose administration.
"If you link a number of modest accumulations into a single pipeline network, that's reasonable," Mr. Dundee said.
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