Furthermore, αsyn fibril-injected mice showed modest motor abnormalities compared to the monomer-injected mice at 3 months after injection.
This may reflect the heterotetrameric nature of ERG channels (e.g. other ERG subunits may partially substitute for ERG3) and/or a high degree of potassium channel redundancy in the nervous system that attenuates the biological impact of modest functional abnormalities of any one channel subunit (39).
A MMP-9 knockout mouse exhibited no or modest structural/functional abnormalities, both on a healthy background and in a model of Alport syndrome [ 40], which could be explained by redundancy of the system based on observations of compensatory upregulation of other MMPs, including MMP-2 [ 41].
"The test shows a mild abnormality.
The diagnostic criteria for TCM include the following: transient hypokinesis, akinesis, or dyskinesis in the left ventricular mid-wall segments with or without apical involvement; absence of obstructive coronary disease; new ECG abnormalities or modest elevation in cardiac troponin; and absence of pheochromocytoma and myocarditis [9].
Nevertheless, modest cardiac and cardiomyocyte mitochondrial abnormalities were detected in 1-year-old Parkin null mice (Hoshino et al, 2013; Kubli et al, 2013).
However, there were no age-related differences in inflammatory or cell surface markers and only modest differences in coagulation-fibrinolysis abnormalities on ED presentation and over the first week (P < 0.05).
Previous studies have demonstrated that abnormal semen profiles are associated with a modest increase in the frequency of sperm chromosomal abnormalities, and that sperm with aberrations in the shape and contours of the head may be carriers of chromatinic defects.
Despite the lack of morphological abnormalities, these mice displayed a modest decrease in total striatal DA levels (Abeliovich et al. 2000), and a reduction in the reserve pool of synaptic vesicles in the hippocampus (Cabin et al. 2002).
Recent MRI studies using diffusion tensor imaging in people with bipolar disorder, 35, 36 although as yet scarce and involving modest samples, have revealed structural white matter abnormalities – located in the frontal lobe and adjacently to the striatum and thalamus.
