There is a paucity of data in F344 rats on toxicokinetics or contributing metabolites or mechanisms to inform mode-of-action conclusions.
These included statistical analyses to adjust for survival differences and cause of death and mode-of-action analyses to inform judgments regarding human relevance of animal bioassay results and susceptible populations or life stages (U.S. EPA 2005b).
Anyway, she is in a mildly brisk mode today, on a mission to inform us about the planet which, of course, we should be thoroughly engaged with, but who has the time, and aren't there a million other things to be worried about?
These experimental design and data interpretation approaches will render genetic toxicology data more useful to inform the mode-of-action-based risk assessment process, and provide the paradigm shift necessary to help bring the field into the 21st century.
There is limited evidence to inform the mode(s) of action leading to differences in tumor type and tumor incidence after early-life exposure compared with exposure later in life.
Other lines of evidence such as toxicology and mode of action can be used to inform the interpretation and use of epidemiologic data in risk assessment.
It then highlights the need to derive deeper understanding of their biological properties in order to inform on possible therapeutic modes of action.
In this mode, a subchannel assignment (SA) map is broadcasted to inform the stations of their assigned subchannels.
Yet to inform policy makers, a broader examination of transport mode choice across different transport modes is required.
First, the node that switches from MODE 2 to MODE 3 only has to perform two actions: the node will first update its proactive routing table entry and then, it has to inform all neighboring nodes of its mode switch.
