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Our method began by removing systematic noise using PCA, thereby implicitly reconstructing the underlying biological processes (expression modes) that reflect protein activity more distinctly than the original expression data.
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In 1926 Gee formed the Chinese Revolutionary Artists Club in San Francisco and moved on to a mode that reflected Cubism with a witty twist, like the painting "Modern Apartment" (1932), whose geometries and sophisticated color contrasts conjure up a woman lounging in a chair next to an imposing telephone that assumes almost sexual significance.
Hence, females evolve to actively prefer males that reflect most strongly on the mode of the female sensitivity function.
However, it would be shortsighted to restrict testing strategies only to methods that reflect specific modes of action because unexpected effects in organisms can occur, as illustrated by the high potency of fluoxetine, a selective serotonin reuptake inhibitor, in algae (Oakes et al. 2010).
Upon ligand binding, the D1-receptor stimulates adenylate cyclase (AC) activity whereas the D2-receptor inhibits AC activity [4], leading us to hypothesize that the specific receptor agonists would lead to distinct transcriptomic and proteomic profiles in the hypothalamus that reflect the mode of action of the distinct receptors.
How can ecotoxicity test methods that reflect the different modes of action of active PPCPs be developed and implemented in customized risk assessment strategies?
They share a common architecture that reflect their biosynthetic and secretory pathways and mode of action.
"Now does that reflect Orangeism?
Wear clothes that reflect you.
Wear clothes that reflect this.
The European Centre for Ecotoxicology & Toxicology of Chemicals (ECETOC 2007) argues for intelligent strategies for chronic ecotoxicity testing that reflects the mode-of-action protein target(s) of a given chemical (e.g., agrochemical, biocide, pharmaceutical).
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