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Moreover the most relevant modes suggested the presence of a hinge between the second and third domain, responsible of most of the protein flexibility and causing large displacements of the third domain.
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As the concentration became higher, the time intensity correlation functions (ICFs) exhibited two modes, suggesting the formation of larger aggregates in addition to the cooperative mode.
This large difference in the mapping rates between the two modes suggests the incompleteness of gene models: there are many reads that were mapped to the genomic regions without annotations.
The device was operated under positive SET and negative RESET operation mode, suggesting the bipolar switching mechanism.
Nevertheless, our observations from operating the device in CW mode suggest the presence of a significant heating effect.
The study of the failure modes suggested that the aluminium layers play a major role in determining failure.
The failure modes suggested that the favourable and central studs failed by concrete cone failure and unfavourable studs failed by rib punching together with crushing of the narrow strip of the concrete in front of the stud.
The great gap between finite and infinite modes suggested by the cursory reading of Ip28 leaves the modal status of tables and persons merely hypothetically necessary.
To further support the notion of different recovery modes suggested by the FRAP beam-size analysis, we employed a complementary approach based on in silico simulations of a system modeled to resemble the dynamics of plaque proteins in FAs, as determined in the FRAP experiments (Figure 3).
The coincidence of experimentally observed dynamic transitions with a few low-frequency modes suggested that the shape of macromolecular assemblies may be a robust parameter that dictates their underlying dynamics.
The similarity of the two modes suggests that the identity of the Cu2+ coordinating ligands in Cu2+/Aβ3 x peptide and Cu2+/Aβ3[pE] x are the same; however, the pH dependence is dramatically different for each peptide, with cyclisation of the negatively-charged carboxylate of Glu3 leading to a reduction in the relative occupancy of the 4N coordination mode.
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