Sentence examples for modes of targeting from inspiring English sources

Two modes of targeting HER2 have been extensively studied in the treatment of HER2-overexpressing breast cancer, both in vitro and clinically.

As discussed above, epigenetic work throws previous modes of targeting individual nutrient consumption into doubt, increasing wariness about substitutability of synthetic or purified substances for whole foods, attention to potentially damaging effects of prior technical 'improvements' to food, and worry about the balance between nutrients in a complex metabolic environment.

The dual specificity resulting from Sendai F-virosomal delivery and tumour specific activation offers a novel mode of targeting HCC at two levels, first by targeted liver cell specific delivery and secondly by promoter/enhancer driven expression only in transformed hepatocarcinoma cells.

We attempted to make this clear in the initial submission by discussing the CBX dependent hierarchical mode of targeting which highlights the fact that other mechanisms exist to target PRC1.

Our alignments of the SBS domain and the juxtaposed salt bridge-forming D451 residue reveal that this mode of targeting may also be conserved in other metazoan Ulp1-like SUMO proteases (Additional file 1).

This may provide an additional mode of targeting this family of receptors that potentially combines the benefits of current anti-angiogenic therapies; having a broader inhibitory profile than antibodies, but without the potential increased toxicity of small molecule tyrosine kinase inhibitors that can affect both intracellular signalling molecules as well as receptor tyrosine kinases.

However, these microparticles could to be exploited in the future as a mode of targeted drug delivery.

Molecular docking analysis was performed as well to predict possible binding modes of target compounds with MDM2.

For GPCRs, allosteric mechanisms impart multiple modes of target modulation (positive allosteric modulation (PAM), negative allosteric modulation (NAM), neutral cooperativity, partial antagonism (PA), allosteric agonism and allosteric antagonism).

Alternately, some of these miRNAs may have different modes of target recognition [ 16].

Our simulations also suggest that enhancer clustering itself is sufficient to generate these two modes of target search.