Sentence examples for modes of substrate from inspiring English sources
However, the subtle structural differences that have recently been observed across a variety of families shed light on their functional diversity, including variations in mechanism of action, differences in the modes of substrate binding, and substrate-assisted orientation of catalytic residues.
Many of these families are functionally heterogeneous, containing members that differ in substrate specificities as well as sites and modes of substrate cleavage.
Understanding the structural biology of protein kinases in detail, including their commonalities, differences and modes of substrate interaction, is necessary for designing high quality inhibitors that will be of true use for cell biology and disease therapy.
These interactions allow for two distinct modes of substrate binding.
These observations suggest that nonproductive modes of substrate binding are possible and may contribute to the low rates of turnover measured for cADO.
The substrates of alkaline ceramidase and Per1 have similar chemical structures in their lipid moieties with two aliphatic chains, suggesting similar modes of substrate binding and catalytic mechanisms.
Through theoretical analysis and numerical simulations, we delineate a map of competing buckling-driven failure modes of substrate-supported thin brittle films in the parameter space of interfacial adhesion and interfacial imperfection size.
Interestingly, two sulfate ions and one diphosphate coordinated with some conserved residues were observed in the active cleft, which affords a better understanding of a possible mode of substrate binding.
As previously reported, the native mycobacterial CoaE shows an ordered mode of substrate binding with DCoA acting as the leading substrate and ATP following it.
Indeed, given IDE's unusual structure, mode of substrate processing and sensitivity to endogenous cofactors [23], it may ultimately be possible to identify compounds that operate in one physiological context but not others (e.g., intracellular vs. extracellular).
We find that the LexA Pa active site possesses a unique mode of substrate recognition.
