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Just one more instance of the old modes of repression being alive and well in Egypt.
We propose that the use of multiple modes of repression ensures inactivation of nos RNA that is translated at earlier stages of oogenesis and maintenance of this inactivate state throughout late oogenesis into embryogenesis.
These findings suggest that Gro employs both Rpd3-dependent and Rpd3-independent modes of repression.
Multiple modes of repression could allow Gro to fine tune gene activity in response to promoter context and cellular environment.
Three modes of repression of targets have been proposed in plants [ 12].
The exact mechanism of repression however remains to be resolved, as three different modes of repression are currently known [ 80].
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This second mode of repression depends on a H3K36-specific HMTase, MES-4.
This raises the possibility that Eds1 also is involved in glucose control of gene expression, which could explain its unusal mode of repression by Mig1 and Mig2.
miR172-mediated cleavage of mRNAs of these target genes has been detected [ 21], but there is strong evidence to suggest that the primary mode of repression of these target genes by miR172 is translational inhibition [ 13, 14].
Based on this active mode of repression, the transcriptional repression of Bcl-6 and Pax5 by Blimp-1 was implemented by having Blimp-1 promote the deactivation step of these two genes.
We show that Pol II phosphorylation is uniquely regulated and transient in PGCs, suggesting that transcriptional repression is continued in the PGCs after the PIE-1 mode of repression is lost.
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