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These studies suggest that using rt-GCM may have a favorable impact on glycemic control regardless of the methods of insulin delivery; however, as pointed out as a limitation of the review, the current literature does not allow a comparison of rt-CGM versus SMBG in patients only using CSII or only using MDI because the modes of insulin delivery were mixed (18).
Patient preference studies comparing drugs of the same class but having differing dosing frequencies have been performed in various disease states including: diabetes (e.g. comparing differing modes of insulin delivery) [ 13]; gastro-esophageal reflux disease [ 14]; osteoporosis [ 15- 19] and irritable bowel syndrome [ 20].
Similar(58)
Several studies assessed the impact on perinatal outcomes of mode of insulin treatment.
Duration of diabetes and mode of insulin administration were obtained from chart review.
Mode of insulin therapy changed importantly during the study period (Supplementary Fig. 1).
The improvement was not completely explained by changes in the mode of insulin treatment.
DISABKIDS results were related to age, gender, duration of diabetes, mode of insulin delivery and metabolic control.
The improvement in glycemic control was not fully explained by demographic factors and changes in the mode of insulin treatment.
Although only 42 of the 252 subjects were not insulin pump users, the mode of insulin delivery did not materially alter the slope.
This hypothalamic mode of insulin action resembles the well-known effect of leptin, suggesting that these two hormones act in concert in the hypothalamus (14).
The association between an intensive glycaemic target and increased risk of ketoacidosis may therefore be confounded by the mode of insulin administration.
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