The goal was to increase the understanding of the tempo and mode of genomic structure and content evolution within the diplomonads.
Microsatellite instability (MSI) is a mode of genomic instability resulting in colorectal cancer development and is associated with poor differentiation, proximal location and failure of chemotherapy (Heinimann, 2013).
The pattern of genome compaction, occasionally offset by lineage-specific expansions of specific gene families, has been noted as a common mode of genomic evolution in unicellular pathogens [ 40] and apicomplexans specifically [ 41, 42].
The considerable heterogeneity in topological support among mitochondrial genes is unusual due to the non-recombining mode of genomic transmission, but echoes similar results obtained for elephantids [ 11] and for chloroplast genes in Asplenium ferns [ 34].
Their relatives reproduce by meiotic parthenogenesis or facultative sexuality, which in combination with the abundance of nematode genomic sequence data, makes them a powerful system in which to study the consequences of reproductive mode on genomic divergence.
40, 42 As in other target cells, 1,25(OH)2D3 elicits long-term and short-term responses in skeletal muscle that involve genomic and non-genomic modes of actions, respectively.
Fitting our model to RNA abundances over time, we find that poliovirus follows the geometric replication mode: multiple iterative generations of genomic replication produce progeny virus.
In addition to the genomic functions of GC, non-genomic modes of GC regulation have been documented.
