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Similarly, two modes of binding to gp120 can be envisioned where CVN either binds gp120 solely through the high affinity site, or binds divalently using both carbohydrate binding sites.
These motifs allow RRMs to bind ssRNA or ssDNA across the face of the β-sheet [ 59, 60], although not hairpin or dsRNA (double-stranded RNA), whereas RAMPs bind ssRNA or hairpin RNA through diverse modes of binding.
The results corroborate evidence for these binding interactions and indicate multiple high-affinity modes of binding.
We hypothesize that the multivalency of the involved molecules leads to different modes of binding.
These findings open up the possibility of designing compounds with new modes of binding.
Docking studies showed structural variations in their modes of binding which explains this unexpected observation.
The resulted modes of binding from docking simulation show a good correlation with the experimentally determined hydrolysis pattern.
These data have shown the great diversity of sizes, shapes, and modes of binding of the substrate binding sites of these mammalian cytochromes P450.
X-ray crystallography was used to determine the structures of the inhibitors in complex with the catalytic kinase domain of Chk2 to verify their modes of binding.
The probable reason for different modes of binding of vesicle-associated membrane protein to botulinum neurotoxin type B and the tetanus toxin is discussed.
The reactions were evaluated by ESI-mass analysis and the binding site and modes of binding were revealed by X-ray crystallization analysis.
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