Sentence examples for modes of allosteric from inspiring English sources
Our findings indicate that AMPK has multiple modes of allosteric activation that may be exploited to design isoform-specific activators as potential therapeutics for metabolic diseases.
This indicates that the P+1 pocket is conformationally malleable and can contribute to the unique modes of allosteric regulation.
Consequently, Hb isoforms that incorporate β-chain products of either HBD or HBB have similar modes of allosteric regulation.
We modeled each step of the pathway according to enzymatic mechanism and known modes of allosteric control resulting in a set of differential equations.
Ligand binding and catalysis require the precise alignment of residues from both subunits; this is very sensitive to relative motion of the subunits as well as to local changes, which underlie the modes of allosteric regulation.
The changes observed in the S1 site when substrate is present in the S2 site suggest a mode of allosteric interaction between the binding sites.
Alternatively, the variation observed at the P+1 pocket may reflect the unique mode of allosteric coupling between the substrate-binding site and active site in CMGC kinases.
Comparative sequence and structural analysis followed by molecular docking and electrostatic surface potential analysis reveal that rearrangements of secondary structure elements, substrate, and inhibitor binding residues are strongly conserved and follow common folding pattern and orientation within monocot and dicot displaying a similar mode of allosteric regulation and catalytic mechanism.
For GPCRs, allosteric mechanisms impart multiple modes of target modulation (positive allosteric modulation (PAM), negative allosteric modulation (NAM), neutral cooperativity, partial antagonism (PA), allosteric agonism and allosteric antagonism).
Development of allosteric inhibitors into efficient drugs is hampered by their indirect mode-of-action and complex structure kinetic relationships.
Although pyruvate dehydrogenase (PDH) gene expression is decreased in MED13cTg hearts, glucose oxidation is not decreased, suggesting that other compensatory modes of PDH regulation (such as allosteric regulation by acetyl CoA, NADH, and ATP, or post-translational regulation by phosphorylation or dephosphorylation) are invoked.
