Your English writing platform
Discover LudwigSuggestions(5)
Exact(40)
MKK3 and MKK6 showed different temporal patterns of activity, indicating distinct modes of activation and physiological function.
The possible modes of activation (mechanical or chemical) and implications of fusion-activated Ca2+ entry (FACE) will be discussed below.
To date, mechanical stimuli are the only means to activate Piezo ion channels and whether other modes of activation exist is not known.
Using specific inhibitors and the existing different modes of activation of signaling pathways we could rule out that activated NFATc2 and NF-kB play a prominent role in regulating NFATc1/A expression.
A possible explanation is the different modes of activation of the complement system.
Thus PIEZO1 sequentially switches between two modes of activation: a pressure-gated and a voltage-gated mode.
Similar(20)
This mode of activation provides another possible pathway for regulating myofibroblast activity by blocking integrin binding to latent TGF-β1, for example by blocking the integrin involved in latent TGF-β1 activation, αvβ5.
Cohen-Armon and co-workers report an alternative mode of activation [ 85], where ERK2 interacts with PARP-1 and activates it independent of DNA strand breaks Figure 4B).
Furthermore, the most effective type of therapy for breast cancer is likely to depend on the mode of activation and the function of the particular pathway component that is aberrantly activated.
A different mode of activation with Bax requiring activation through BH3-only proteins and Bak auto-activating when the inhibition is removed would appear to provide a reason for the presence of both.
These observations imply a mode of activation indicative of peptide-induced structural shifts imposed to the protease domain rather than disturbing the PDZ protease interface.
More suggestions(15)
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com