Socio-demographic, care-related and clinical variables at baseline were analyzed as potential moderators of intervention response at 12-months follow-up.
In addition to these outcome analyses, comparative cost analysis of the two programs, potential mediators of intervention success, and baseline moderators of intervention effects will be explored to better determine which subgroups do best with which type of intervention.
Moderators of intervention outcomes are typically baseline characteristics that interact with the intervention to affect outcomes.
Potential moderators of intervention effect will be examined including demographics, ethnicity, parity, mental health (also an outcome), smoking status and weight loss history.
The MOVE study will utilise a post-intervention segmentation approach in that it will test for potential moderators of intervention effectiveness to determine whether some population groups may be particularly responsive to the interventions being tested.
B. White et al. not only compared multiple interventions to increase stool blood test uptake in a national screening program but also examined multiple moderators of intervention effects to assess what is needed by whom.
This trial seeks to address some of these methodological shortcomings, in that: it is adequately powered; it is theory-based; moderators of intervention effect are being measured; there are a number of different strategies in place to retain participants; there is a detailed process evaluation assessing issues like fidelity; and, there is a cost effectiveness analysis.
Two separate meta-analyses have indicated than an important moderator of intervention effects in patient-only interventions is the total time spent with the therapist delivering the intervention [ 11, 12].
Next, for models predicting PA, we elaborated on the basic 2 × 3 ANOVA framework described above by including one of seven continuous neighborhood environment measures (e.g., perceived safety) as a potential moderator of intervention effects on PA, resulting in 7 models (1 per moderator) for each of the 9 PA measures.
