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Socio-demographic, care-related and clinical variables at baseline were analyzed as potential moderators of intervention response at 12-months follow-up.
In addition to these outcome analyses, comparative cost analysis of the two programs, potential mediators of intervention success, and baseline moderators of intervention effects will be explored to better determine which subgroups do best with which type of intervention.
Moderators of intervention outcomes are typically baseline characteristics that interact with the intervention to affect outcomes.
Potential moderators of intervention effect will be examined including demographics, ethnicity, parity, mental health (also an outcome), smoking status and weight loss history.
The MOVE study will utilise a post-intervention segmentation approach in that it will test for potential moderators of intervention effectiveness to determine whether some population groups may be particularly responsive to the interventions being tested.
B. White et al. not only compared multiple interventions to increase stool blood test uptake in a national screening program but also examined multiple moderators of intervention effects to assess what is needed by whom.
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The aim of this study is to provide an overview of controlled outcome studies and to investigate the overall efficacy and moderators of interventions targeted at reducing depressive symptoms in this population.
However, a wider range of synthesis methods has emerged in the last decade addressing different types of questions (e.g., realist synthesis to explore mediating mechanisms and moderators of interventions).
Two separate meta-analyses have indicated than an important moderator of intervention effects in patient-only interventions is the total time spent with the therapist delivering the intervention [ 11, 12].
Next, for models predicting PA, we elaborated on the basic 2 × 3 ANOVA framework described above by including one of seven continuous neighborhood environment measures (e.g., perceived safety) as a potential moderator of intervention effects on PA, resulting in 7 models (1 per moderator) for each of the 9 PA measures.
Additionally, we anticipate being able to utilize data on maternal and child outcome measures to obtain preliminary indications about potential moderators of the intervention and inform hypotheses about which intervention may be most suitable when offered in a clinical psychiatric outpatient context.
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