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Therefore, restoration of the redox state in infected cells may be an effective way to control viral infection, by inhibiting viral replication, moderating the inflammatory response, and improving the host cells' immune responses.
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Moreover, EnStef could moderate the inflammatory reactions at the gill attachment site by inhibiting cysteine peptidases released by the immune cells.
Thus, PrtV may also moderate the inflammatory effects through degradation of VCC.
In addition, T. gondii infection was previously shown to induce IL-10 production in vivo and this cytokine may therefore moderate the inflammatory response of macrophages [31].
Thus interventions that moderate the inflammatory response may prove to reduce adverse outcomes[ 9].
The effect on the immune system has been previously attributed to the down regulation of the inflammatory response, moderating the production of pro inflammatory cytokines and immunoglobulins in murine models for irritable bowel syndrome [ 13].
Platelet-directed killing may moderate the local inflammatory responses to live parasites, or dead parasite toxins and exudate could contribute to the inflammatory and cell-damaging milieu.
The aim of the present minireview was to examine the evidence in the last decade for the association of the systemic inflammatory response with the range of symptoms including appetite loss, weight loss, fatigue and pain and identify a rational clinical approach to moderate the systemic inflammatory response and reduce symptoms experienced in patients with cancer.
To date, there have been few attempts to moderate the systemic inflammatory response in patients with cancer.
Because reactive oxygen species (ROS) participate in the pathophysiology of endotoxemic shock, it has been suggested that moderating the oxidative stress and inflammatory reaction would translate into improving the microcirculation and oxygenation of the tissues.
The release of TGF-β1 by renal or by infiltrating cells in the damaged kidney moderates the inflammatory reaction and helps to heal the damaged tissue.
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