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The regimen was moderately well tolerated.
Sorafenib was moderately well tolerated, with skin rash, hand-foot syndrome, and diarrhea being the most frequent adverse effects.
This regimen was moderately well tolerated and may become established as one of the treatment options in patients with a good PS.
The maximum tolerated dose in the combination was 20 mg panobinostat given orally three times weekly during three out of every four weeks, which was only moderately well tolerated with substantial hematological toxicity (thrombocytopenia) [ 79].
In the authors' opinion, potentially effective novel agents may be investigated relatively early in patient populations with imatinib-refractory GIST, prior to treatment with sunitinib or regorafenib, as sunitinib and regorafenib are only moderately well tolerated and responses to them may remain relatively short lived.
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In conclusion, this study demonstrated that single and multiple doses of FM-VP4 for 4 weeks are safe and well tolerated by moderately hypercholesterolemic subjects.
However, our physiological results indicate that sitting is probably well tolerated in mild to moderately affected patients with stroke.
Treatment with epratuzumab 2400 mg cd was well tolerated in patients with moderately to severely active SLE, and associated with improvements in disease activity.
Importantly, Cnp heterozygosity (in mice) and moderately reduced CNP expression levels (in humans) are well tolerated until an advanced age.
Despite the availability since the 1980′s of an inexpensive, efficacious, and moderately well-tolerated therapy, that can cure 90% of cases, tuberculosis (TB) continues to be a major worldwide health problem, with 8.6 million new cases and 1.3 million deaths in 2012 [ 1].
Treatment was well tolerated.
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