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She had high blood pressure and diabetes, both diagnosed recently and moderately well controlled.
Moderately well controlled maternal diabetes was achieved with twice daily glucose checks and insulin injections.
Overall they had moderately well controlled diabetes, with a median (25th to 75th percentile) HbA1c of 6.9% (5.8 to 7.8%).
Moderately well controlled hyperglycemia, as occurs with most human pregnancies, results in hypertrophy of the neonatal heart.
Subjects with T2DM moderately well controlled with metformin, a thiazolidinedione, or metformin plus a thiazolidinedione were recruited from 5 centers in Canada and the Netherlands.
Several studies have described the cardiomyopathy seen in the macrosomic offspring of mothers with moderately well controlled gestational diabetes [ 2, 4- 6, 22].
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These observations rather support the importance of controlling postprandial glucose and the underlying insulin resistance as therapeutic targets for improvement of cardiac function [ 3], at least in moderately well-controlled type 2 diabetes, in line with earlier reports [ 5, 18, 27, 28, 31, 33].
Overweight/obese individuals with moderately well-controlled type 2 diabetes were recruited by advertisement.
All but one home in our study had a baseline TTR above 60% (considered moderately well-controlled [ 5]).
This limitation, however, should not detract from the clinically-relevant message that MDI with AI does improve diastolic cardiac function in moderately well-controlled patients with type 2 diabetes.
Was pain well controlled?
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