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We therefore introduced E137K into T-20S138A (T-20E137K/S138A) and revealed that T-20E137K/S138A moderately suppressed replication of T-20S138A-resistant HIV-1.
Further characterization of the longer peptide revealed that release of liposome contents (i) occurred at a pH of ∼6, (ii) became less efficient as the size of the encapsulated cargo increased, and (iii) was moderately suppressed in cholesterol-containing liposomes.
In the course these studies, we found that the widely used Ih blocker ZD7288 moderately suppressed evoked spiking.
That means the M cone is highly suppressed by the photostimulus, the S cone is only slightly suppressed or not at all, and the L cone is moderately suppressed.
In the FBS-containing media, the BK inhibitor paxilline (10 µM) had no effect on cell growth, while the IK1 blocker clotrimazole (10 µM) moderately suppressed cell proliferation of U251 (Fig. 5).
To assess whether the inhibition of Na+ channels can reproduce the delay of the action potential onset, Na+ channels were moderately suppressed with a Class IC anti-arrhythmic, specific Na+ channel blocker, pilsicainide [19], [20].
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Using overexpressed catalytic-dead RhoA GAP mutants, we find ARAP3-R982A moderately suppresses podosome formation, while DLC1-R677E has no significant effect.
When administered i.v. twice weekly for 4 weeks, AS-06 moderately suppresses the growth of subcutaneous tumor of RPMI8226 xenograft, while AS-29 potently suppresses tumor growth.
In animal models of arthritis, systemic treatment with IL-10 and adenovirus-mediated transfer of viral IL-10 moderately suppresses the development of arthritis, but is significantly more effective when combined with IL-4 [ 19- 24].
Mutants in hst-2 have previously been shown to only moderately suppress the kal-1 -dependent branching phenotype in contrast to mutants in other modification enzymes such as the HS C-5 glucuronyl epimerase hse-5 and the HS sulfotransferases hst-6 or hst-3.2, which almost completely suppressed the phenotype (Bülow and Hobert 2004; Tecle et al. 2013).
In D-cblK26 mutant clones, the GMR-EGFRDN phenotype is moderately strongly suppressed (Fig. 2F) implying that loss of D-cbl partially restores the activity of endogenous EGFR inhibited by EGFRDN.
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