Sentence examples for moderately potent activity from inspiring English sources

Results of biological studies revealed that the majority of compounds exhibited potent to moderately potent activity and among them, 12 displayed potency comparable to that of the imipramine with %DID of 37.95 and 44.84 in the FST and TST, respectively.

In the light of this moderately potent activity, we have now assessed the trypanocidal and antiplasmodial activity of a larger series of huprines.

Huprines have been found to display a moderately potent activity against cultured bloodstream forms T. brucei, particularly those bearing a chlorine atom at position 3 or a bulky butyl or tert-butyl substituent at position 9.

Compound (177) showed a moderately potent anti-protozoal activity against P. falciparum K1 strain (IC50 3.3 µM), Trypanosoma brucei rhodesiense (IC50 3.1 µM) and completely inactive against T. cruzi and Leishmania donovani and have shown poor cytotoxicity against a mammalian cell-line (IC50 170 µM).

As can be seen in Table  2, this modification is sufficient to transform the compounds from agonists into a moderately potent blockers of oxytocic uterotonic activity (e.g. [ cis-Apc]AVP, pA2 = 7.47).

Codeine is a moderately potent narcotic, which requires demethylation to active metabolite (morphine).

Compound 3 is a moderately potent and nonselective inhibitor of PI3Ks and also inhibits PI3Kβ potently (data not shown).

These compounds, which were screened at the NCI during the past 20 years, resulted in approximately 4000 compounds labeled as 'moderately active.' In our study, chalcone 11 shows the most potent activity with an IC50 of 2 ± 1 μM against purified IN in the presence of both Mn2+ and Mg2+ as cofactors.

The first-generation inhibitors are moderately potent and nonselective and therefore the results obtained from their application may not be a direct result of modulating SphK1 activity but rather a consequence of off-target effects.

The anticholinesterase activity of phenylcinnamide derivatives was determined against Electric Eel acetylcholinesterase (EeAChE) and horse serum butyrylcholinesterase (hBChE) and some of the compounds appeared as moderately potent inhibitors of EeAChE and hBChE.

Bufotoxin, a moderately potent poison secreted in the skin of many anuran amphibians, especially the typical toads (genus Bufo).