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Compound 3 is a moderately potent and nonselective inhibitor of PI3Ks and also inhibits PI3Kβ potently (data not shown).
Bufotoxin, a moderately potent poison secreted in the skin of many anuran amphibians, especially the typical toads (genus Bufo).
The nonclassical analogs 6 16 were moderately potent against pathogen DHFR or TS.
Hybridization of weak inhibitors of ACC2 provided a novel, moderately potent but lipophilic series.
In addition, 9k was a moderately potent inhibitor for h-ChEs.
A short synthesis was developed and moderately potent ICE inhibitors were identified (IC50 values <100 nM).
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22 This is compared with an approximate 3% incidence with moderately-potent comparators.
In general, they inhibited proliferation and induced erythroid differentiation of K562 human chronic myeloid and MEL mouse leukemia cells, being only slightly or moderately less potent in comparison to novel vitamin D3 hydroxyderivatives with a full side-chain or to 1,25(OH)2D3.
We found lambda1 could be reliably calculated from ictal EEG data and that the global mean, maximum, and standard deviation of lambda1 were smaller in the more therapeutically potent moderately suprathreshold ECT and in therapeutic responders.
Modifications at the 1,3-benzodioxole and phenyl phamacophoric units resulted in the identification of a number of potent compounds (moderately selective with respect to the α1b-AR), in binding experiments.
Despite its small size, Psilocybe semilanceata is considered a "moderately active to extremely potent" hallucinogenic mushroom (meaning the combined percentage of psychoactive compounds is typically between 0.25% to greater than 2%), and of the 12 mushrooms compared, only 3 were more potent: P. azurescens, P. baeocystis, and P. bohemica.
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