Patients had normal renal function and were moderately ill as assessed by severity of illness scores (Table 1).
The severity of illness (0 = not to moderately ill vs. 1 = markedly to extremely ill) was assessed by the Clinical Global Impressions Scale [ 25].
The variable ILL was dichotomised into not/mildly ILL consisting of 0 or 1 symptom or moderately ILL consisting of 2 to 4 symptoms.
Patients had to be at least moderately ill at the start of the study and experiencing an exacerbation of their illness that required an intensification of the level of psychiatric care during the 2 weeks before entering the study.
For the moderately ill, the drug may shorten the duration of symptoms by about a day.
To investigate the use of nebulized 3% hypertonic saline (HS) for treating viral bronchiolitis in moderately ill hospitalized infants by a prospective, randomized, double-blinded, controlled, multicenter trial.
He seems moderately ill at ease twitching his way through the role of the stern federal agent, flying into random spasms of mugging when the flow of jokes in the dialogue turns thin.
Discriminant validity was supported based on SOFI score comparisons for patient groups based on PANSS and BACS scores (p < 0.05); SOFI scores differed between borderline and moderately ill patients as measured by the CGI-S (p < 0.05).
Limitations include the study requirement that patients be at least moderately ill and experiencing acute psychotic exacerbation, a potential selection bias in the readiness to respond to measures, and small sample sizes for some analyses.
Linear regression models of all three MacCAT-CR scales identified working memory as a predictor; negative symptoms made a small contribution to the understanding and appreciation scores.Negative symptoms and aspects of neurocognitive functioning were correlated with decision-making capacity in this large sample of moderately ill subjects with schizophrenia.
The study physicians assigned each subject a Clinician Global Impression of Severity (CGIS [12]) score of 1 = "normal, not at all ill," 2 = "borderline ill," 3 = "mildly ill," 4 = "moderately ill," 5 = "markedly ill," 6 = "severely ill," or 7 = "among the most extremely ill patients".
