For example, Figure 5 shows that a mildly contagious disease like SARS may be thwarted by partial coverage (≈75%) with a moderately efficacious vaccine (≈60% vaccine efficacy).
Memantine has been shown to be moderately efficacious in the treatment of moderate to severe Alzheimer's disease.
These characteristics could be a disadvantage for evaluating drug candidates that are moderately efficacious and could be overlooked when tested in such an aggressive model, as opposed to the common more moderate models which may recapitulate the slower progression of AD in humans.
Cisplatin-based chemotherapy is used for the treatment of advanced stage cases, but is only moderately efficacious.
Conclusions: Zinc-ORS was moderately efficacious in reducing the severity of acute diarrhea without increasing vomiting or reducing ORS intake.
Although both were moderately efficacious, neither could induce the durable, robust humoral and cellular immunity commonly seen in HCMV seropositive subjects.
Although both were moderately efficacious, neither could induce the durable, robust humoral and cellular immunity commonly seen in CMV seropositive subjects.
In monotherapy two treatment cycles were moderately efficacious in the Lu7336 model but showed good anti-tumor activity in the KRAS mutant Lu7187 model (26% and 80% tumor growth inhibition, respectively).
Effect of vaccine characteristics and transmission intensity: In low transmission settings, low or moderately efficacious blood-stage vaccines avert comparable proportions of disease episodes and deaths to those averted by PEV with comparable efficacy for all delivery modalities.
In line with our previous simulations, we find that moderately efficacious pre-erythrocytic vaccines applied via EPI do not have any substantial effect on malaria transmission, (results not shown), because only a small proportion of the population is protected.
