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The qualitative values are assigned according to the PONDR® VLXT values by comparison to the mean values of Table 2. Here, the proteins whose percentages of predicted disordered residues are between 30 40% were considered as moderately disordered.
M1 is predicted to be moderately disordered.
Nef protein and integrase are predicted to be moderately disordered, whereas both protease and reverse transcriptase contain the least amount of predicted disorder.
The HIV matrix protein is predicted to be highly disordered, whereas the influenza virus matrix protein is predicted to be only moderately disordered (or somewhat ordered) by PONDR® VLXT.
For example, protein sequences have been categorized on the basis of the overall degree of disorder (i.e., the fraction of residues that is shown or predicted to be disordered), resulting in groups of structured proteins (0 10% disorder), moderately disordered proteins (10 30% disorder), and highly disordered proteins (30 100% disorder).
The proteins are labeled as "predicted to be ordered," "moderately disordered," or "very disordered".
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According to this classification, only 11 human proteins related to the controlled cell death pathways shown in Figure 1 are characterized by low disorder scores, whereas the absolute majority of the PCD-related proteins are moderately or highly disordered.
The developers provide clinically defined cut-off points to indicate whether a patient is "within the normal range" (score of 0 7), or in a "mildly" (8 10), "moderately" (11 14), or "severely" (15 21) disordered state.
Of the 300 patients, 99 had schizophrenia, 120 had major affective disorders, and 81 had non-psychotic mild to moderately severe mental disorders (anxiety disorders, and mild-moderately severe depression).
Conduct disorder (CD) is a moderately heritable psychiatric disorder of childhood and adolescence characterized by aggression toward people and animals, destruction of property, deceitfulness or theft, and serious violation of rules.
The GAD-7 is also moderately good at identifying panic disorder, social anxiety disorder and post-traumatic stress disorder.
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CEO of Professional Science Editing for Scientists @ prosciediting.com