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Conversely, growth of the CD133− population was only moderately attenuated with c-Myc knockdown (Figure 4).
Based on the extent of attenuation, we further classified the mutants as severely attenuated (with a reduced fold-change of >4 SD from the mean of WT fold-change) and moderately attenuated (with a reduced fold-change of 2>SD<4 from the mean of WT fold-change) (Fig. 2B) (Table S1 and Table S2).
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Estimated benefits of cycling and gardening on respiratory mortality were moderately attenuated among those with high levels of NO2 exposure compared with moderate or low exposure.
After further adjustment for hormonal factors (either testosterone, SHBG or FAI), the strength of the associations was moderately attenuated, however, women with irregular cycles still had a 6% increase in mean QUS.
A similar TR46/Y121F/T289A mechanism is associated with voriconazole therapy failure with moderately attenuated susceptibility to itraconazole and posaconazole.
> -wrap-foot> > -wrap-foot> When maternal and paternal smoking were analyzed together, both continued to predict offspring ADHD symptoms, with moderately attenuated effect sizes (mothers: β = 0.18, 95% CI: 0.10, 0.26; fathers: β = 0.15, 95% CI: 0.09, 0.22 (Table 1)).
We also found that health behaviours did not explain the association between social capital and health, except for physical activity, which moderately attenuated the association of participation with both self-rated health and psychological well-being.
As for the napping analysis, although the adjustment for physical activity variables made little difference, additional controls for BMI alone or with physical activities moderately attenuated this association.
In our study of the population without dementia the presence of vascular disease significantly increased the risk of depression, apathy, anxiety, irritability and sleep problems, with these associations moderately attenuated after adjusting for cognitive impairment.
Additionally adjusting for mGFR moderately attenuated the association of self-reported frailty with death (HR 1.48, CI 1.08 2.00).
Additionally, the likelihoods of having diabetes and high blood pressure associated with insufficient sleep were moderately attenuated 20-400%) but were not fully explained by obesity (Model 3).
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