Exact(1)
However, unlike in colon cancer tumor, l-CaD was not detected in most cell lines, and only four cell lines including SNU-C5, CaCo2, HCT-116, SW480 and SW620 showed moderated expression of l-CaD.
Similar(59)
This data provided evidence for the up-regulation of RNF41 in B-CLL, since immunohistochemistry analysis demonstrated weak-moderated expression of RNF41 in B-CLL samples, while peripheral blood mononuclear cells from healthy blood donors showed negative-weak expression of the protein.
For the 258 genes with somatic, sex-biased expression, moderated- t-tests were performed [ 16], comparing gene expression in tud progeny males and females to determine at which stage the gene displays somatic, sex-differential expression (Table 2).
These analyses yielded log2 fold changes, average log2-expression, moderated t-statistics and false discovery rates for each probe.
When the conjugate hydrophobicity was high enough to form micelles below 0.11 mg/mL, the reduction in transgene expression became moderated but was accompanied with a sharp decrease in cellular viability.
Genes were ranked for differential expression by moderated t-statistics.
To compare differential gene expression a moderated t-test (limma) with Benjamini-Hochberg correction was performed.
For assessing differential expression the moderated t-statistics was used as proposed by [ 21] in all the 3 studies.
Of note, the solvent alone already had a moderated effect on protein expression, while Sorafenib substantially downregulated all investigated proteins.
Performing a moderated t-statistic differential expression analysis on each data set (Additional File 9 - Supplementary results: Comparison of the ovarian cancer data set and the melanoma data set), we found that the melanoma data set contained 96 DE genes (p-value < 0.1) while the ovarian cancer data set had only 13 DE genes.
Test for differential expression: Differentially expressed genes were identified by fitting the moderated t-test linear model to the data (separately for each gene).
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