For gastrointestinal tolerability (moderate or severe nausea, dyspepsia, or abdominal pain), one patient fewer would suffer for every 28 treated with celecoxib than with NSAID.
Studies in PHN, which include a majority of patients who are elderly, show clinically significant efficacy from tricyclic antidepressants, opioids and gabapentinoids and moderate-to-good tolerability in most cases.
The vaccine was safe; tolerability was moderate, with a number of adverse events related to local injection site reactogenicity.
It showed good tolerability and moderate activity in some of these patients [ 167].
Of these, the most paramount were issues surrounding the feasibility and tolerability of moderate to high-intensity aerobic training in women with a history of breast cancer.
This study was designed to determine the bronchodilator effects of GSK961081, the dose and dosing interval (using trough FEV1 at day 29 as the primary outcome), as well as safety and tolerability in moderate and severe COPD patients.
Routine laboratory parameters (see above), immunological parameters (see above) and estimation of tolerability (bad, moderate, good, excellent) by the subjects were documented every 4 weeks always in the morning to the same time (± 1 hour) as baseline investigations.
The overall incidence of treatment-related AEs (most were mild to moderate) was low, suggesting excellent tolerability of anidulafungin even in critically ill patients.
Hence, in the present study we combined both, advanced IMRT/IGRT techniques for a better tolerability, and a moderate hypofractionated simultaneous integrated boost (SIB) to the prostate for a probably higher biological effectiveness.
In 2011, an oral inhibitor of receptor for advanced glycation end products (RAGE), PF-04494700, was tested for ten weeks in patients with mild to moderate AD and showed good tolerability and no serious adverse effects.
All three vaccine candidates, low dose AMA-1/AS01B, full dose AMA-1/AS01B and full dose AMA-1/AS02A, had a good tolerability profile but caused moderate reactogenicity, manifested specifically by local erythema and swelling.
