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The 'moderate decreasing pain class' (32.5 %) was comprised of girls showing moderate to rather low headache frequencies across time, with significant changes.
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Autonomic features are less likely to occur in patients with moderate to severe rather than excruciating attacks of pain.
Fever was more likely to occur among patients with care-need levels ≥3 than ≤2, those who are wheelchair users or bedridden rather than ambulatory and those with moderate-to-severe rather than none-to-mild cognitive impairment.
Fever is more likely to occur among individuals with care-need levels ≥3 than ≤2, those who are wheelchair users or bedridden rather than ambulatory, and those individuals with moderate-to-severe rather than none-to-mild cognitive impairment.
Fever was more likely to arise in the wheelchair users or bedridden than in ambulatory individuals (HR 1.9 (95% CI 1.3 to 2.8; p<0.01); in patients with moderate-to-severe rather than those with none-to-mild cognitive impairment (HR, 1.7 (95% CI 1.1 to 2.6, p=0.01); and in those whose care-need levels were ≥3 rather than ≤2 (HR, 4.5 (95% CI 2.9 to 7.0; p<0.01).
It has been suggested that moderate-to-severe, rather than minimal-to-mild endometriosis, represents progressive disease, as the latter may only be a transient phase in an ongoing process that often results in cytolysis of recently implanted endometrial cells (36).
Linkage studies in non-BRCA1/2 breast cancer families and segregation analysis in ovarian cancer families suggest that a large fraction of the residual familial risks is due to multiple alleles of moderate to low penetrance rather than additional high penetrance susceptibility genes [5], [6].
Even when these highly advanced instruments are used, it is moderate to high exposure rather than very low background traces that is detectable.
We chose to assess risk of moderate to severe AKI rather than all AKI because this severity (corresponding to KDIGO stage 2 and 3) has been shown to be associated with a significantly increased incidence of clinically important outcomes such as need for renal replacement therapy, in hospital death, and persistent renal dysfunction [ 2, 3].
However, this previous finding might suffer from overestimation of the causal effect of treatment since early intervention was more likely to be administered to patients with mild to moderate severity rather than to those with severe conditions such as coma.
"The first two years we had rather moderate to high calf losses, and the first year we had some adult losses," Kantar said.
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