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Even at 4 weeks, there was a persistence of moderate tissue response with numerous macrophages, lymphocytes, and giant cells).
GPC results indicated that undoped PHT did not degrade and hence could influence the moderate tissue response throughout the study.
Random PLGA-undoped PHT nanofibrous implant established moderate tissue response characterized by the presence of predominant lymphocytes, macrophages, fibroblasts, and few giant cells).
By 2 weeks, the tissue surrounding the aligned PLGA-doped PHT nanofibers demonstrated a moderate tissue response characterised by a predominant infiltrate of lymphocytes, macrophages, and giant cells).
Our results for tissue response to random PLGA-undoped PHT nanofibers demonstrated the moderate tissue response which did not decrease over time.
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Furthermore, all composites showed a similar tissue response, with decreasing capsule thickness over time and a persistent moderate inflammatory response at the implant interface.
By mimicking elasticity ranges of biological tissues (∼0.5 kPa for soft tissue (e.g., brain), ∼10 kPa for moderate tissue (e.g., muscle), and >30 kPa for hard tissue (e.g., bone)) in a biomaterial, one can influence cellular response to that material, which can then prolong circulation times for drug delivery vehicles or facilitate cell proliferation on tissue scaffolds.
Vivian Finlay survived long enough to have substantial tissue response, her face lacerated and bruised, her eyes swollen shut.
Nine studies presented mechanical tissue response.
All granules demonstrated excellent tissue response.
Heterogeneity, in this context, refers to variation in tissue response, tissue composition, tissue physiology, tissue phenotype and tissue genotype.
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