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A cut-off score of 10 or higher relates to good sensitivity of 0.84 and moderate specificity of 0.63.
First, the high sensitivity and moderate specificity of the Pareidolia test in differentiating between dementia with Lewy bodies and Alzheimer's disease may be associated with an inclusion bias.
However, we confirmed the high sensitivity and moderate specificity of the JAAM scoring system using the ISTH overt DIC criteria as the gold standard.
However the specificity was generally not high, the best was a moderate specificity of 70% from a hypothetical protein expressed by an IgM-detected clone (GenBank accession no. 7898829).
The moderate specificity of the MLDA was in particular due to a significantly higher number of false positive anti-CL IgM determined in the DC and NHS (9/144) groups compared to the ELISA data (1/144, P = 0.019742).
An HbA1c threshold of 1 SD above the normal mean (5.9%) showed a very high sensitivity of 77.7%95%5% confidence interval 72.6% to 82.3%) and a moderate specificity of 78.2% (77.0% to 79.4%) for detecting undiagnosed diabetes.
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22 Studies using internal validation to compare clusters of ICD codes for detecting maltreatment-related injury with case notes or child protection agency data reported high specificity for clinician concerns about maltreatment, 7 and moderate specificity for definitive evidence of maltreatment or child protection agency notification.
Using the cut-off value recommended by the manufacturer for human sera (25 units), we confirmed the high sensitivity (70%/36%) and moderate specificity (91.7%/97.2%) of the SmD1 peptide-based assay as previously reported [ 15, 20]; in our patient cohort, we found a sensitivity of 45.8% and a specificity of 77.8% (see Table 1).
In B cells, functional immunoglobulin genes are generated by gene rearrangement (V D J joining), giving rise to a primary repertoire of B cells producing antibodies of moderate specificity and affinity for many potential antigens.
As a consequence of the moderate specificity in this study, the scores of the symptom-free controls might have been overestimated.
A high sensitivity with a moderate specificity in the case of bone erosions was observed by the Z-Score, presenting the best data for MCP articulation of the index finger with 87.9% versus 55.2% (area under the curve 0.806, P < 0.01).
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