This study also indicated that IgM mAbs and defective Ig mAb have broad binding, moderate specificity and low affinity.
Existing automatic detection techniques show high sensitivity and moderate specificity, and detect seizures a relatively long time after onset.
Faux et al. [9] demonstrated that 'immediate verbal recall and quantitative recording of headache' alone can predict PCS with low to moderate specificity and sensitivity.
In a further quality validation step, the conjugates were presented to an animal's immune system and polyclonal antibody titres with moderate specificity were obtained.
However, since it has a moderate specificity (62%) with a positive predictive value (PPV) of only 35%, then lesions detected should be confirmed with digital subtraction cerebral angiography (venous phase) particularly those involving the transverse and sigmoid sinus.
Early improvement predicted response and remission after 5 12 weeks of treatment with high sensitivity (85%; 95%-CI: 84.3 to 85.7) and low to moderate specificity (54%; 95%-CI: 53.1 to 54.9).
While the sensitivity was moderate, specificity and positive predictive values were relatively low, and negative predictive values were high.
These results demonstrate that a high-affinity, moderate specificity synbody can be readily generated to another protein using this procedure.
We started with 4-aminopyridine (4-AP) typically considered as Kv blocker preferentially affecting IA, but with moderate specificity [24], [29].
Furthermore, the classical potassium channel antagonist TEA, which is typically used to block IK, but with moderate specificity, was applied to the cells [24], [28].
The cause of the moderate specificity was further investigated.
