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Five patients (4.6%) with no adverse side effects were classified as highly radioresistant; 36 (33.3%), 44 (40.7%), and 10 patients (9.3%) with mild to moderate skin reactions were classified as, respectively, moderately radioresistant, average, and moderately radiosensitive; and 13 patients (12%) with pronounced signs of radiation acute sensitivity were considered highly radiosensitive (Fig. 1).
Six reference substances (formaldehyde, alpha-hexylcinnamaldehyde, fragrance mix, thimerosal, mercaptobenzothiazole and phthalic anhydride); all mild to moderate skin sensitizing chemicals, were assessed in a study, which compared the use of 3 and 9 induction applications.
Based on dot matrix photothermolysis theory [18], ablative fractional laser produces an array-like arrangement of tiny laser beam and disrupts the skin barrier by creating ablative microscopic vertical channels surrounded by a zone of thermal damage, inducing a wound healing response to moderate skin appearance [19 22].
In conclusion we found that the majority of patients with moderate skin and soft tissue infections can successfully be treated in an ED observation setting, although the discharge rate after observation treatment is lower than other diseases such as chest pain [24 26].
In our study as well, mCRC patients with severe and moderate skin rash presented significantly higher TTP and OS compared with those with mild and no rash.
Mild to moderate skin irritation improved over a follow-up period of 7 days.
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MFU-V is best suited for patients with mild-to-moderate skin and soft tissue laxity.
Eight patients developed mild-to-moderate skin rash and eight patients reported mild-to-moderate diarrhoea.
The maximum tolerated dose was determined to be 600 mg b.i.d., with frequently noted side effects being myelosuppression, mild-moderate skin rash and transient indirect hyperbilirubinaemia.
Grades 1 2 included cases with mild-to-moderate skin changes, no or mild gastrointestinal involvement and no or mild decrease in clinical performance, while grades 3 4 had more significant changes.
If present, dehydration was graded as mild (dry mucus membranes, decreased tears and urine output), moderate (decreased skin turgor), or severe (excessively decreased skin turgor, tachycardia, low blood pressure, anuria, absence of tears) [ 11].
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