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For the situation in which the effects of the studies are logarithms of odds ratios, the chi-square distribution is much too conservative for moderate size studies, although it may be asymptotically correct as the individual studies become large.
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In conclusion, this moderate size study did not reveal any statistically significant differences in pulmonary function between generally healthy HTLV-I or -II infected persons and comparable HTLV seronegatives.
Because birth weight is measured on a continuous scale, even moderate-size studies often have excellent statistical power to detect small decrements.
We acknowledge that this may have resulted in an oversampling of small and moderate sample size studies reporting significant and large effect sizes.
Having analysed a heterogeneous patient cohort of moderate size, our study is not without limitations.
When BiPAP was compared with conventional medical therapy (without CPAP) in two moderate size randomized controlled studies, there were no significant differences in the incidence of new onset acute myocardial infarction [ 8, 15].
Weaknesses include moderate size of the study, which made us unable to detect PFT differences that were less than about ten percent.
The moderate size of the study population limits our ability to detect statistically significant interactions and raises the possibility of type II error, which underscores the need to test our hypotheses in future studies.
Although the moderate size of this study prevented statistical analysis of any potential association between calcium metabolism-related disorders and elevated PINP, this analysis suggests that there was no association between serum PINP elevation during daily teriparatide treatment and serum calcium concentration or calcium metabolism-related disorders in Japanese subjects.
The proteins are of moderate size for typical NMR studies, and this collection has representative structural diversity and assignment difficulty.
For example, the rs833061 variant in the VEGFA gene shows the strongest protective effect, but was investigated in two studies of moderate size.
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