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Different from saw1-ΔRBD and - ΔFBD, saw1-K221R apn1Δ apn2Δ cells were viable but exhibited slower growth and stronger MMS sensitivity than apn1Δ and2Δ, and only moderate sensitization of tdp1Δ cells to CPT.
Erroneously classifying patients as low risk for clinical reactivity to peanut presents obvious problems, while erroneously classifying them as high risk based on low or moderate sensitization to peanut leads to a negative psychosocial impact and reduced quality of life [9], [10].
While m4 did not react to food extracts or components, he presented with a moderate sensitization towards mites and cat.
The results showed that the transfer of functional p53 resulted in a marked (tenfold) reduction of cellular chemosensitivity to the multinuclear platinum complex but in a moderate sensitization to cisplatin.
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As expected, reduced Bcl-xL expression resulted in moderate carboplatin sensitization in both cell lines (IC50 = 88.80 µM for shRNA control, 70.70 µM for Bcl-X shRNA (SKOV3-CR); 91.36 µM for shRNA control, 58.00 µM for Bcl-X shRNA A2780-CRR)) (Figures 5B and 5C).
More drastically, TNF α alone failed to promote cell death in Caco-2 cells, and cells only showed a moderate response after sensitization with actinomycin D (ActD).
In addition, inhalation of moderate doses of LPS during sensitization induces regulatory responses that, after multiple allergen exposures, limit the severity and longevity of asthma-like features.
Recent results include a major increase in allergic sensitization and a moderate increase in physician-diagnosed asthma among children 7 to 8 years of age, from 5.7% in 1996 to 7.4% in 2006, while the prevalence of current wheeze did not change significantly [ 16].
In women with moderate-to-severe asthma, only sensitization to cat was associated with no improvement in asthma severity at follow-up.
The two lines with moderate DCF-DA fluorescence exhibited IR sensitization upon PARP1 inhibition.
In women with moderate-to-severe asthma at baseline, sensitization to cat was associated with a higher risk of having no improvement in asthma severity at the second follow-up (59.3% vs 33%; p = 0.04).
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