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The sensations were rated on a 0 10 visual analog scale (VAS): 0, no perception; 3, vague perception of moderate sensation; and 5, pain detection threshold.
The anchor words were 0, no sensation; 1, vague perception of mild sensation; 2, definite perception of mild sensation; 3, vague perception of moderate sensation; 4, definite perception of moderate sensation; 5, pain detection threshold; 6, slight pain; 7, moderate pain; 8, medium pain intensity; 9, intense pain; and 10, unbearable pain.
Every somatic or visceral sensation was evaluated on the scale, on the basis of its perceived intensity, and orientation descriptors were provided indicating that score 1 represented vague perception of light intensity, score 2 represented definite perception of light intensity, and scores 3 and 4 represented vague and definite perception of moderate sensation, respectively.
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rTMS was well tolerated, capsaicin application only caused local rush and a light to moderate burning sensation.
Particularly the plaque-like lesions were associated with a moderate burning sensation.
The only adverse event was a mild to moderate burning sensation at the infusion site, which decreased upon slowing the infusion rate.
The only adverse effect was a mild to moderate burning sensation at the application site during the first week of treatment in one-third of women.
Table 3 Characteristic of the patient Patient: F.M (n = 1) Age 73 Gender Male Paralyzed side Left Days from onset 90 Superficial sensation Moderate Pain sensation Normal Vibratory sensation Moderate Proprioception Moderate Motor impairment Brs; LE/VI MMSE 28/30 Brs Brunstrom's recovery stage, LE Lower extremity, MMSE Mini mental state examination.
All of the ADRs were mild in severity, except for moderate foreign body sensation in the eyes reported in one subject.
In terms of side effect, most patients (81%) experienced transient, mild to moderate loss of sensation within distinct maxillary nerve regions; 65% of events resolved within 3 months.
The anti-NGF antibodies were generally very well tolerated (consistent with a benign profile in 6-month primate studies [ 13]), with mild to moderate, transient peripheral sensation changes as the only consequences [ 7].
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